Determination of fetal chromosome aberrations from fetal DNA in maternal blood: has the challenge finally been met?
نویسندگان
چکیده
منابع مشابه
Determination of fetal chromosome aberrations from fetal DNA in maternal blood: has the challenge finally been met?
The analysis of cell-free fetal nucleic acids in maternal blood for prenatal diagnosis has been transformed by several recent profound technology developments. The most noteworthy of these are 'digital PCR' and 'next-generation sequencing' (NGS), which might finally deliver the long-sought goal of noninvasive detection of fetal aneuploidy. Recent data, however, indicate that NGS might even be a...
متن کاملIs cell-free fetal DNA from maternal blood finally ready for prime time?
H prenatal genetic diagnosis for numeric chromosomal abnormalities (trisomy 21) at last reached its desired goal of becoming a definitive test (not a screen)? Can we relegate our invasive diagnostic procedures— chorionic villus sampling (CVS) and amniocentesis—to the museum? The contributions of Bianchi et al1 (see p. 890) and others earlier this year2,3 take us a considerable distance. Of cour...
متن کاملAn Effective Method for Detecting Y-chromosome Specific Sequences of Circulating Fetal DNA in Maternal Plasma During the First-trimester
Background and Aims: New advances in the use of cell-free fetal DNA (cffDNA) in maternal plasma of pregnant women has provided the possibility of applying cffDNA in prenatal diagnosis as a non-invasive method. One of the applications of prenatal diagnosis is fetal gender determination. Early prenatal determination of fetal sex is required for pregnant women at risk of X-linked and some endocrin...
متن کاملFetal and embryonic hemoglobins in erythroblasts from fetal blood and fetal cells enriched from maternal blood in fetal anemia.
BACKGROUND AND OBJECTIVES To determine whether there is a delay or reversal in switch mechanisms from embryonic (e and z) to fetal (g) hemoglobins accompanying the erythroblastosis of anemic fetuses and whether an increased erythroblast count in fetal blood is associated with an increase in feto-maternal cell trafficking. DESIGN AND METHODS Fetal and maternal blood samples were obtained from ...
متن کاملThe potential usefulness of free fetal DNA in maternal blood for prenatal fetal gender determination in multiple pregnancies.
We applied a noninvasive prenatal test for the determination of fetal gender in multiple pregnancies by using free fetal DNA circulating in maternal blood in order to evaluate whether the quantification of male DNA could distinguish the fetal gender and the number of male and female fetuses in multiple pregnancies. We enrolled consecutively 44 women with twin pregnancies between 11-14 weeks of ...
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ژورنال
عنوان ژورنال: Expert Reviews in Molecular Medicine
سال: 2011
ISSN: 1462-3994
DOI: 10.1017/s1462399411001852